Among women with normal cytology and cervical HPV infections, one can often find multiple HPV types, a great variability in the HPV type distribution including a significant presence of low risk types. Some variability in the ranking thereafter has been described. In most populations, anal cancer is twice as common in females as in males and the incidence is particularly high amongst homosexual males.
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Cancers of the vagina is consistently rarer that vulvar cancer. Cervical cancer is a major global concern, with the vast majority of the disease burden carried by the developing world, and is predicted to increase dramatically over the next decade without significant intervention. Cancer of the cervix uteri has been historically the number one cancer in women. In most populations, anal cancer is twice as common in females as in males and the incidence is particularly high amongst homosexual males. The most common HPV types associ-.
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Moreover, within the developed countries, cervical cancer also clusters in the lower socioeconomic strata, signaling the lack of appropriate screening as one of the major determinants of the occurrence of the invasive stages of the disease. One recent estimate concluded that cervical cancer is the biggest single cause of years of life lost YLL from cancer in the developing world. Case-control studies estimated that the risk of penile cancer is reduced about threefold among circumcised men.